The Role of AGT, AMPD1, HIF1α, IL-6 Gene Polymorphismsin the Athletes’ Power Status: A Meta-Analysis
(Gokhan Ipekoglu, Tugba Cetin, Necdet Apaydin, Tugce Calcali, Ebru Senel)

This meta-analysis was designed to investigate the relationship between genetic polymorphisms (AGT rs699, AMPD1 rs17602729, HIF1α rs11549465, IL-6 rs1800795) and power athletes’ status. Only case-control studies were included in the meta-analysis. A systematic search of the PubMed and Web of Science databases was performed to identify relevant studies and 23 studies met the inclusion criteria for the meta-analysis. The data from the included studies were pooled and analyzed using a random effects or fix effects model. The effect size was calculated as the odds ratio or a risk ratio with 95% confidence intervals. The results showed that certain genetic polymorphisms, AGT rs699 Thr allele, HIF1A rs11549465 Ser allele and AMPD1 rs17602729 C allele, were significantly more prevalent in power athletes (p < 0.05). When examining the genotype frequency distribution of AGT rs699 and AMPD1 rs17602729, significant differences were found in both the dominant and recessive models (p < 0.05). The results indicate that these gene polymorphisms play a role in power athlete status, however, new and more comprehensive studies are needed to confirm these results.

IPEKOGLU, G., CETIN, T., APAYDIN, N., CALCALI, T., SENEL, E. (2023). The Role of AGT, AMPD1, HIF1α, IL-6 Gene Polymorphisms in the Athletes’ Power Status: A Meta-Analysis. Journal of Human Kinetics, 89, 77-87. https://doi.org/10.5114/jhk/169262

IPEKOGLU, Gokhan, Tugba CETIN, Necdet APAYDIN, Tugce CALCALI, and Ebru SENEL. “The Role of AGT, AMPD1, HIF1α, IL-6 Gene Polymorphisms in the Athletes’ Power Status: A Meta-Analysis”. Journal of Human Kinetics 89 (2023): 77-87. doi:10.5114/jhk/169262.

IPEKOGLU, G., CETIN, T., APAYDIN, N., CALCALI, T., and SENEL, E. (2023). The Role of AGT, AMPD1, HIF1α, IL-6 Gene Polymorphisms in the Athletes’ Power Status: A Meta-Analysis. Journal of Human Kinetics, 89, pp.77-87. https://doi.org/10.5114/jhk/169262

IPEKOGLU, Gokhan et al. “The Role of AGT, AMPD1, HIF1α, IL-6 Gene Polymorphisms in the Athletes’ Power Status: A Meta-Analysis.” Journal of Human Kinetics, vol. 89, 2023, pp. 77-87. doi:10.5114/jhk/169262.