Does exercise training affect NO/GC/cGMP pathway in the brain?

The mechanism(s) behind brain adaptation to physical training has not been fully investigated. The exercise-induced rise in energy turnover results in increased metabolic activity both in skeletal muscle, liver and fat tissue and some metabolic products may cross the blood brain barrier. In turn, this may influence brain metabolism and neuronal signaling pathways. In this paper we provide a concise overview of the field. Additionally, preliminary indications are given that NO/GC/cGMP may play a significant role in the signaling pathway involved in the control of movements (coordination).